反応 #156596

反応方程式

Trifluoromethanesulfonic anhydride

2-[4-((R)-3-dimethylaminopyrrolidin-1-yl)-3-fluorophenyl]-6-hydroxy-3,4-dihydro-2H-isoquinolin-1-one

pyridine

→

Trifluoromethanesulfonic acid 2-[4-((R)-3-dimethylaminopyrrolidin-1-yl)-3-fluorophenyl]-1-oxo-1,2,3,4-tetrahydroisoquinolin-6-yl ester

溶媒

dichloromethane

反応条件

後処理

1. 1
   その他the mixture was partitioned between water and dichloromethane
2. 2
   乾燥the organic phase was dried over magnesium sulfate
3. 3
   濃縮concentrated
4. 4
   その他The product with the molecular weight of 501.50 (C22H23F4N3O4S) was obtained in this way

実験手順

Trifluoromethanesulfonic anhydride (2.06 g) was added to a solution of 2-[4-((R)-3-dimethylaminopyrrolidin-1-yl)-3-fluorophenyl]-6-hydroxy-3,4-dihydro-2H-isoquinolin-1-one (1.5 g) and pyridine (0.64 g) in dichloromethane (40 mL) at 0° C. After 30 minutes, the mixture was partitioned between water and dichloromethane, and the organic phase was dried over magnesium sulfate and concentrated. The product with the molecular weight of 501.50 (C22H23F4N3O4S) was obtained in this way; MS (ESI): 502 (M+H+).

出典