反応 #156591

反応方程式

4-Butoxy-2-(2-chloroethyl)benzoyl chloride

[(R)-1-(4-amino-2-fluorophenyl)pyrrolidin-3-yl]methylcarbamic acid tert-butyl ester

→

{(R)-1-[4-(6-Butoxy-1-oxo-3,4-dihydro-1H-isoquinolin-2-yl)-2-fluorophenyl]pyrrolidin-3-yl}methylcarbamic acid tert-butyl ester

反応条件

後処理

1. 1
   その他The product with the molecular weight of 511.64 (C29H38FN3O4) was obtained in this way

実験手順

4-Butoxy-2-(2-chloroethyl)benzoyl chloride was reacted by method A with [(R)-1-(4-amino-2-fluorophenyl)pyrrolidin-3-yl]methylcarbamic acid tert-butyl ester. The product with the molecular weight of 511.64 (C29H38FN3O4) was obtained in this way; MS (ESI): 512 (M+H+).

出典