反応 #1564

反応方程式

N-[(4-fluoro-3-nitrophenyl)carbamoyl]glycine, ethyl ester

hydrogen

→

title product

収率 60.8%

N-[(3-Amino-4-fluorophenyl)-carbamoyl]glycine, ethyl ester

収率 60.8%

溶媒

ethyl acetate

反応条件

後処理

1. 1
   ろ過The reaction mixture is then filtered
2. 2
   温度cooled in an ice-bath until a solid forms
3. 3
   ろ過The solid is collected by filtration
4. 4
   その他air-dried

実験手順

A mixture of N-[(4-fluoro-3-nitrophenyl)carbamoyl]glycine, ethyl ester (8 g, 0.029 mol) and 5% platinum on activated carbon (0.5 g) in ethyl acetate is hydrogenated at 50 psi until hydrogen uptake is complete. The reaction mixture is then filtered and cooled in an ice-bath until a solid forms. The solid is collected by filtration and air-dried to give the title product as a white solid (4.5 g, mp 152°-153° C.).

出典