反応 #1563934

反応方程式

NaBH4

5-(2,5-difluorophenyl)-3,4-dihydro-2H-pyrrole

→

title compound

収率 79.8%

2-(2,5-difluorophenyl)pyrrolidine

収率 79.8%

溶媒

MeOH H2O

反応条件

後処理

1. 1
   その他The reaction mixture was quenched with 1N aqueous HCl solution
2. 2
   抽出extracted with DCM
3. 3
   乾燥dried over anhydrous sodium sulphate
4. 4
   濃縮concentrated under reduced pressure

実験手順

NaBH4 (12 g, 314.9 mmol) was added to a solution of 5-(2,5-difluorophenyl)-3,4-dihydro-2H-pyrrole (28.5 g, 157.4 mmol) in a mixture of MeOH:H2O (4:1, 250 mL) and stirring was continued at 25-35° C. for 2 h. The reaction mixture was quenched with 1N aqueous HCl solution and basified with 2N aqueous NaOH solution, extracted with DCM, dried over anhydrous sodium sulphate and concentrated under reduced pressure to afford 23 g of the title compound.

出典