反応 #1563933

反応方程式

TFA

tert-butyl 5-(2,5-difluorophenyl)-2,3-dihydro-1H-pyrrole-1-carboxylate

→

title compound

収率 83.7%

5-(2,5-difluorophenyl)-3,4-dihydro-2H-pyrrole

収率 83.7%

溶媒

EtOAc

DCM

反応条件

後処理

1. 1
   濃縮The reaction mixture was concentrated under reduced pressure
2. 2
   その他to afford the crude, which
3. 3
   洗浄washed with saturated NaHCO3 solution
4. 4
   乾燥dried over anhydrous sodium sulphate

実験手順

TFA (108 g, 940 mmol) was added to a solution of tert-butyl 5-(2,5-difluorophenyl)-2,3-dihydro-1H-pyrrole-1-carboxylate (53 g, 188 mmol) in DCM (300 mL) at 0° C. and stirring was continued at 20-35° C. for 2 h. The reaction mixture was concentrated under reduced pressure to afford the crude, which was diluted with EtOAc, washed with saturated NaHCO3 solution, dried over anhydrous sodium sulphate to afford 28.5 g of the title compound.

出典