反応 #1563931

反応方程式

HCl

(R)-1-((S)-tert-butylsulfinyl)-2-(2,5-difluorophenyl)pyrrolidine

→

title compound

(R)-2-(2,5-difluorophenyl)pyrrolidine Hydrochloride

溶媒

Dioxane

反応条件

後処理

1. 1
   濃縮After which the reaction mixture was concentrated under reduced pressure
2. 2
   その他to afford the crude product
3. 3
   その他The crude product was purified
4. 4
   洗浄by washing with diethyl ether

実験手順

4M HCl solution (in Dioxane) (75 mL) was added to stirred solution of (R)-1-((S)-tert-butylsulfinyl)-2-(2,5-difluorophenyl)pyrrolidine (15 g, 52.19 mmol) in Dioxane (25 mL) and stirring was continued at 20-35° C. for 4 h. After which the reaction mixture was concentrated under reduced pressure to afford the crude product. The crude product was purified by washing with diethyl ether to afford 7.5 g of the title compound as a white solid.

出典