反応 #1563923

反応方程式

1-(2,2-dimethoxyethoxy)-4-fluorobenzene

trifluoroacetic acid

→

title compound

2-(4-fluorophenoxy)acetaldehyde

溶媒

chloroform

反応条件

後処理

1. 1
   温度heat to 65° C.
2. 2
   workup.STIRRINGstir for 4 h
3. 3
   濃縮Concentrate the mixture under reduced pressure

実験手順

Dissolve 1-(2,2-dimethoxyethoxy)-4-fluorobenzene (1.00 g, 4.99 mmol) in chloroform (5.0 mL) and treat the mixture with trifluoroacetic acid (0.755 mL, 9.99 mmol). Stir the mixture at room temperature for two days, then heat to 65° C. and stir for 4 h. Concentrate the mixture under reduced pressure to furnish the title compound as a colorless oil in ca. 70% purity, as indicated by 1H NMR analysis (550 mg, 71% uncorrected yield). 1H NMR (400 MHz, CDCl3): δ 9.85 (t, J=0.5 Hz, 1H), 7.00 (dd, J=8.9, 8.5 Hz, 2H), 6.85 (dd, J=9.5, 4.3 Hz, 2H), 4.55 (br s, 2H).

出典