反応 #1563920

反応方程式

methyl (S)-4-(1-tert-butoxycarbonylaminoethyl)benzoate

hydrogen chloride

→

title compound

収率 97.1%

methyl (S)-4-(1-aminoethyl)benzoate hydrochloride

収率 97.1%

反応条件

後処理

1. 1
   濃縮Concentrate the mixture under reduced pressure

実験手順

To methyl (S)-4-(1-tert-butoxycarbonylaminoethyl)benzoate (1.00 g, 3.58 mmol), add hydrogen chloride (4 M in dioxane, 5 mL, 20 mmol) and stir the resulting mixture at room temperature for one hour. Concentrate the mixture under reduced pressure to furnish the title compound as a white solid (750 mg, 97% yield). 1H NMR (400 MHz, DMSO-d6): δ 8.57 (br s, 3H), 7.99 (d, J=8.4 Hz, 2H), 7.65 (d, J=8.4 Hz, 2H), 4.47 (q, J=6.7 Hz, 1H), 3.84 (s, 3H), 1.50 (d, J=6.8 Hz, 3H).

出典