反応 #1563891

反応方程式

bis(2-bromoethyl)amine

Compound 25

2-amino-N-(2-methoxyphenyl)-6-(4-nitrophenylthi-o)benzamide

NaOH

→

solid

収率 82.0%

N-(2-methoxyphenyl)-2-((4-nitrophenyl)thio)-6-(piperazinyl)benzamide

収率 82.0%

溶媒

DMF

反応条件

後処理

1. 1
   その他to get crude product
2. 2
   ろ過The crude solid was filtered
3. 3
   洗浄washed several times with water
4. 4
   その他purified by silica gel column chromatography (1:3 v/v ethyl acetate/petroleum ether)

実験手順

Compound 25 (1.0 equiv.) was dissolved in DMF (40 mL) at room temperature. To this mixture bis(2-bromoethyl)amine (1.0 equiv.) was added, following the addition of NaOH (2.0 equiv.). After being stirred for 2 Hours at room temperature, the reaction mixture was poured into ice-cold water (200 mL) to get crude product. The crude solid was filtered and washed several times with water and purified by silica gel column chromatography (1:3 v/v ethyl acetate/petroleum ether) to provide a yellow solid (380.9 mg, 82% yield).

出典