反応 #156320

反応方程式

6-Bromo-5,7-difluoro-quinoline

tributyl(vinyl)tin

→

title compound

5,7-Difluoro-6-vinyl-quinoline

溶媒

dioxane

反応条件

後処理

1. 1
   その他The solvent was removed
2. 2
   その他the residue was purified by MPLC with hexane and EtOAc

実験手順

6-Bromo-5,7-difluoro-quinoline (v) (1 g, 4.10 mmol), tetrakis(triphenylphosphine)palladium(0) (47 mg, 0.041 mmol) and tributyl(vinyl)tin (1.34 g, 4.10 mmol) were put together with dioxane (3.7 mL) in a microwave reactor and stirred for 25 min at 150° C. under microwave irradiations. The solvent was removed and the residue was purified by MPLC with hexane and EtOAc. The title compound was obtained as a colorless oil (tR 1.1 min (conditions 2), MH+=192).

出典