反応 #156308

反応方程式

4-{[(2S)-2-fluoropropyl]oxy}pyridine

acetic acid

→

4-{[(2S)-2-fluoropropyl]oxy}piperidine

収率 43.2%

溶媒

methanol

反応条件

後処理

1. 1
   workup.ADDITIONwas added
2. 2
   ろ過The reaction mixture was filtered through celite
3. 3
   濃縮the filtrate was concentrated under reduced pressure
4. 4
   その他The residue was purified by basic silica gel column chromatography (chloroform/methanol)

実験手順

2.2 g of 4-{[(2S)-2-fluoropropyl]oxy}pyridine was added to a solution of 22 mL of acetic acid in 22 mL of methanol, and 500 mg of 10% palladium on carbon (wet type) was added thereto under an argon atmosphere. The mixture was stirred at room temperature overnight under a hydrogen atmosphere of 3 atm. The reaction mixture was filtered through celite and the filtrate was concentrated under reduced pressure. The residue was purified by basic silica gel column chromatography (chloroform/methanol) to obtain 988 mg of 4-{[(2S)-2-fluoropropyl]oxy}piperidine.

出典