反応 #155740

反応方程式

4-fluoro-benzoic acid methyl ester

KOtBu

4-fluoracetophenone

water

→

desired compound

1,3-Bis-(4-fluoro-phenyl)-1,3-propanedione

溶媒

THF

反応条件

後処理

1. 1
   ろ過filtered
2. 2
   濃縮the filtrate was concentrated
3. 3
   その他the residue was purified by chromatography on silica gel (cyclohexane/EE: 98:2)
4. 4
   その他The solvent was removed

実験手順

9.27 g KOtBu was added to 109 mg 18-Krone-6 and 5 mL 4-fluoracetophenone in 150 mL THF. After 30 min at RT 10.7 g 4-fluoro-benzoic acid methyl ester was added and stirred for 3 h at RT. The reaction was decomposed with water and filtered, the filtrate was concentrated and the residue was purified by chromatography on silica gel (cyclohexane/EE: 98:2). The solvent was removed and 3.9 g of the desired compound was obtained.

出典