反応 #155397

反応方程式

HCl

2-chloro-4-(methylsulfonyl)benzoyl chloride

5-amino-1-(2-methoxyethyl)tetrazole

water

→

2-chloro-4-(methylsulfonyl)-N-(1-(2-methoxyethyl)tetrazol-5-yl)-benzamide

溶媒

EA

pyridine

反応条件

後処理

1. 1
   その他The organic phase is separated off
2. 2
   洗浄washed with 2N HCl and brine
3. 3
   乾燥dried over Na2SO4
4. 4
   濃縮concentrated
5. 5
   その他purified by RP—HPLC (acetonitrile/water)

実験手順

176 mg (0.75 mmol) of 2-chloro-4-(methylsulfonyl)benzoyl chloride, 145 mg (1.0 mmol) of 5-amino-1-(2-methoxyethyl)tetrazole in 2 ml of pyridine are stirred at 60° C. for 12 h. 0.1 ml of water is then added, the mixture is stirred at 60° C. for 30 min and EA and 2N HCl are added. The organic phase is separated off and washed with 2N HCl and brine, dried over Na2SO4, concentrated and purified by RP—HPLC (acetonitrile/water). Yield 66 mg (23%).

出典