反応 #155390

反応方程式

10-methylacridan-9-carboxylic acid

10-Methylacridan-9-carboxylic acid

thionyl chloride

yellow acid

→

acid chloride

10-Methylacridan-9-carboxylic acid chloride

溶媒

dichloromethane

反応条件

後処理

1. 1
   その他Into a 50 mL round bottom flask equipped with magnetic stirrer and under an argon atmosphere
2. 2
   濃縮The light red brown solution was concentrated under reduced pressure
3. 3
   その他the residue was dried for 15 min

実験手順

Into a 50 mL round bottom flask equipped with magnetic stirrer and under an argon atmosphere was charged a solution of 0.305 parts of 10-methylacridan-9-carboxylic acid (77) in 15 mL of dichloromethane and cooled to 5° C. (ice-water). Then, 1.05 parts of thionyl chloride was added to the cold yellow acid solution and stirred for 1.5 hr at a temperature below 15° C. The light red brown solution was concentrated under reduced pressure and the residue was dried for 15 min to give acid chloride (78).

出典