反応 #1553208

反応方程式

4-aminophenyl ethanol

NBS

DMF

→

2-(4-Amino-3-bromophenyl)ethanol

溶媒

ethyl acetate

反応条件

後処理

1. 1
   洗浄washed with water (300 mL×4)
2. 2
   乾燥dried over Na2SO4
3. 3
   濃縮concentrated in vacuo

実験手順

A solution of 4-aminophenyl ethanol (34 g, 0.25 mol) and NBS (35 g, 0.20 mol) in DMF (660 mL) was stirred at RT overnight. Then the mixture was diluted with ethyl acetate (2 L), washed with water (300 mL×4), dried over Na2SO4, concentrated in vacuo to give the crude product 2-(4-Amino-3-bromophenyl)ethanol. 1H NMR (400 MHz, CDCl3) δ 7.26 (d, J=1.6 Hz, 1H), 6.93 (d, J=1.6 Hz, 1H), 6.70 (s, 1H), 4.44 (br, 1H), 3.76 (t, J=6.4 Hz, 2H), 2.71 (t, J=6.4 Hz, 2H).

出典