反応 #155319

反応方程式

5-Methylbenzofuran-7-ylamine

ethanol

→

5-methyl-2,3-dihydrobenzofuran-7-ylamine

収率 87.6%

溶媒

dichloromethane

反応条件

後処理

1. 1
   その他followed by conduction of catalytic reduction at room temperature under ordinary pressure
2. 2
   その他The catalyst was removed by celite filtration
3. 3
   その他condensed under reduced pressure
4. 4
   乾燥dried over anhydrous magnesium sulfate
5. 5
   濃縮concentrated to dryness under reduced pressure

実験手順

5-Methylbenzofuran-7-ylamine (1.3 g, 8.8 mmol) and 10% palladium carbon (500 mg) were added to ethanol (50 ml), followed by conduction of catalytic reduction at room temperature under ordinary pressure. The catalyst was removed by celite filtration, and the obtained filtrate was condensed under reduced pressure. The residue was dissolved in dichloromethane, dried over anhydrous magnesium sulfate, and then concentrated to dryness under reduced pressure, giving a white powder of 5-methyl-2,3-dihydrobenzofuran-7-ylamine (1.15 g, yield: 87%).

出典