反応 #155312

反応方程式

2,2-Dimethyl-5-[(3-propoxynaphthalen-2-ylamino) methylene][1,3]dioxane-4,6-dione

diphenyl ether

→

5-propoxy-4H-benzo[f]quinolin-1-one

収率 106.3%

反応条件

後処理

1. 1
   温度the mixture was heated with a mantle heater
2. 2
   温度maintained
3. 3
   温度under reflux for 2 hours
4. 4
   その他purified
5. 5
   濃縮The purified product was concentrated to dryness under reduced pressure

実験手順

2,2-Dimethyl-5-[(3-propoxynaphthalen-2-ylamino) methylene][1,3]dioxane-4,6-dione (4.19 g, 11.7 mmol) was added to diphenyl ether (15 ml), and the mixture was heated with a mantle heater and then maintained under reflux for 2 hours. The mixture was cooled to room temperature and purified using silica gel column chromatography (dichloromethane:methanol=70:1→9:1). The purified product was concentrated to dryness under reduced pressure, giving a dark brown powder of 5-propoxy-4H-benzo[f]quinolin-1-one (3.15 g, yield: 61%).

出典