反応 #1552084

反応方程式

methyl 4-(4-butylphenyl)benzoate

NaOH

→

4-(4-butylphenyl)benzoic acid

収率 71.1%

溶媒

THF H2O

反応条件

後処理

1. 1
   温度was heated
2. 2
   温度to reflux overnight
3. 3
   その他THF was removed
4. 4
   ろ過The resulting mixture was filtered
5. 5
   洗浄the cake was washed with water
6. 6
   その他dried

実験手順

A mixture of methyl 4-(4-butylphenyl)benzoate (89.0 g, 0.332 mol), NaOH (26.6 g, 0.664 mol) in THF/H2O (500 mL/100 mL) was heated to reflux overnight. After TLC showed the reaction was complete, THF was removed. The residue was adjusted pH ˜3-4 with 2 N HCl solution. The resulting mixture was filtered and the cake was washed with water, dried to give 4-(4-butylphenyl)benzoic acid (60.0 g, yield: 71.1%), as a white solid. (ESI) m/z 255.0 (M+H)+.

出典