反応 #1552037

反応方程式

palmitoyl chloride

N-hydroxysuccinimide

triethylamine

→

N-palmitoyloxy-Succinimide

溶媒

chloroform

反応条件

後処理

1. 1
   洗浄After washed with 500 mL of water three times
2. 2
   乾燥the resultant solution was dried over magnesium sulfate
3. 3
   濃縮was then concentrated under reduced pressure
4. 4
   その他to obtain 260.3 g (quant) of a colorless solid

実験手順

To a solution of 165 mL (0.544 mol) of palmitoyl chloride in 1 L of chloroform while cooled with ice with stirring, 69.8 g (0.598 mol) of N-hydroxysuccinimide was gradually added, and 83.1 mL (0.598 mol) of triethylamine was added dropwise thereto over 30 minutes. The resultant solution was stirred for 30 minutes while cooled with ice and for another 7 hours during which the resultant solution gradually reached room temperature. After washed with 500 mL of water three times, the resultant solution was dried over magnesium sulfate and was then concentrated under reduced pressure to obtain 260.3 g (quant) of a colorless solid.

出典