反応 #1552036

反応方程式

4-Nitro-N-(tert-octyl)benzamide

hydrogen

→

4-amino-N-(tert-octyl)benzamide

収率 76.1%

溶媒

ethyl acetate

反応条件

後処理

1. 1
   その他15 minutes
2. 2
   ろ過After filtration, concentration of the solvent

実験手順

4-Nitro-N-(tert-octyl)benzamide (30 g, 0.108 mol) dissolved in 200 ml of ethyl acetate is hydrogenated, in a 500 ml hydrogenator, in the presence of 4.8 g of 10% palladium-on-charcoal containing 50% of water, as catalyst (hydrogen pressure: 8-10 bar), at a temperature of 70-75° C. for 1 hour and 15 minutes. After filtration, concentration of the solvent and drying under vacuum, 20.4 g (yield: 76%) of 4-amino-N-(tert-octyl)benzamide are obtained in the form of a light yellow powder, which is used as it is in the following stage.

出典