反応 #1552019

反応方程式

methyl ethyl ketone

4-hydroxybiphenyl

6-bromo-1-hexanol

potassium carbonate

→

6-(4-phenylphenoxy)hexane-1-ol

収率 75.8%

溶媒

methylene chloride

反応条件

後処理

1. 1
   温度This solution was refluxed for 24 hours
2. 2
   洗浄rinsed with water three times
3. 3
   その他The organic phase was then separated
4. 4
   乾燥dried over magnesium sulfate
5. 5
   workup.DISTILLATIONthe solvent was distilled off
6. 6
   workup.DISSOLUTIONThe residue was dissolved in toluene
7. 7
   その他purified by recrystallization

実験手順

To 80 mL of methyl ethyl ketone, 9.05 g (50 mmol) of 4-hydroxybiphenyl, 10.20 g (60 mmol) of 6-bromo-1-hexanol, and 20.7 g (150 mmol) of potassium carbonate were added. This solution was refluxed for 24 hours and then cooled to room temperature. This solution was diluted with 200 mL of methylene chloride and rinsed with water three times. The organic phase was then separated and dried over magnesium sulfate, and the solvent was distilled off. The residue was dissolved in toluene and purified by recrystallization to provide 10.25 g of 6-(4-phenylphenoxy)hexane-1-ol.

出典