反応 #1551174

反応方程式

5-amino-4-cyano-1-(2,2-diethoxyethyl)-pyrazole

→

7-cyano-1H-imidazo[1,2-b]pyrazole

収率 91.5%

溶媒

hydrochloric acid

反応条件

後処理

1. 1
   温度The reaction mixture was cooled under ice-water
2. 2
   ろ過the resultant solid was collected by filtration
3. 3
   洗浄washed with ice-water
4. 4
   乾燥dried over phosphorus pentoxide in vacuo to the crude product
5. 5
   その他The product was crystallized from ethanol (400 ml)

実験手順

A solution of 5-amino-4-cyano-1-(2,2-diethoxyethyl)-pyrazole (23 g) in lN hydrochloric acid (205 ml) was heated at 60-70° C. The mixture was stirred for 0.5 hour at the same condition. The reaction mixture was cooled under ice-water and the resultant solid was collected by filtration, washed with ice-water and dried over phosphorus pentoxide in vacuo to the crude product. The product was crystallized from ethanol (400 ml) to give 7-cyano-1H-imidazo[1,2-b]pyrazole (12.4 g).

出典