反応 #1543033

反応方程式

N-(2-mercapto-ethyl)malonamic acid

ammonia

→

N-(2mercaptoethyl)malonamide

反応条件

後処理

1. 1
   その他was kept below or equal to 30° C
2. 2
   workup.STIRRINGStirring
3. 3
   その他A slight cloudiness was removed by filtration on sintered glass
4. 4
   その他The filtrate was evaporated to dryness at reduced pressure
5. 5
   その他The solid obtained
6. 6
   その他was recrystallized from ethyl acetate
7. 7
   ろ過After filtering
8. 8
   その他drying in vacuum at 50° C.

実験手順

31 g of methyl ester of N-(2-mercapto-ethyl)malonamic acid obtained in Example 3a) were added to 220 cm3 of aqueous 20% solution of aqueous ammonia, with stirring, while the temperature was kept below or equal to 30° C. Stirring was continued for 1 hour at ambient temperature. A slight cloudiness was removed by filtration on sintered glass. The filtrate was evaporated to dryness at reduced pressure. The solid obtained was recrystallized from ethyl acetate. After filtering and drying in vacuum at 50° C., 27 g of N-(2mercaptoethyl)malonamide were obtained in the form of a white solid with a melting point of 100° C.

出典