反応 #1531290

反応方程式

2,5-dibromo-3-methyl-pyridine

(R)-2-methyl-piperazine

→

title compound

1-(5-Bromo-3-methyl-pyridin-2-yl)-3-(R)-methyl-piperazine

溶媒

DMA

反応条件

後処理

1. 1
   その他Partition the reaction mixture between water and EtOAc
2. 2
   洗浄Wash the EtOAc layer with water (1×) and brine (1×)
3. 3
   乾燥dry (Na2SO4)
4. 4
   濃縮concentrate under reduced pressure

実験手順

Heat a solution of 2,5-dibromo-3-methyl-pyridine (Chontech Inc.) (2.0 g, 7.97 mmol), (R)-2-methyl-piperazine (3.2 g, 31.9 mmol) in DMA at 130° C. for 16 h. Partition the reaction mixture between water and EtOAc. Wash the EtOAc layer with water (1×) and brine (1×), dry (Na2SO4) and concentrate under reduced pressure to give the title compound as a solid.

出典