反応 #1528400

反応方程式

ethyl 3-diethylphosphono-propionate

benzyl 3-diethylphosphonopropionate

water

hexane

→

3-Diethylphosphonopropionic Acid

溶媒

ethanol

反応条件

後処理

1. 1
   ろ過the active carbon is filtered off
2. 2
   workup.DISTILLATIONthe solvent is distilled out
3. 3
   その他The product results as a colourless oil which
4. 4
   その他slowly solidifies to a colourless solid at room temperature
5. 5
   その他be removed

実験手順

40.3 mmol of benzyl 3-diethylphosphonopropionate (12.1 g) are dissolved in 100 ml of ethanol, and 2 g of catalyst (5% Pd/C) are added. After stirring under an H2 atmosphere for 4 h, the active carbon is filtered off, and the solvent is distilled out. The product results as a colourless oil which slowly solidifies to a colourless solid at room temperature. The product is slightly contaminated with ethyl 3-diethylphosphono-propionate which, where appropriate, can be transferred into the organic phase by shaking several times with water and hexane, and be removed.

出典