反応 #1528399

反応方程式

2-(4-fluoro-phenyl)-1-phenyl-ethylamine

2-chloroethyl isocyanate

→

title compound

収率 65.6%

(4,5-Dihydro-oxazol-2-yl)-[2-(4-fluoro-phenyl)-1-phenyl-ethyl]-amine

収率 65.6%

溶媒

THF

反応条件

後処理

1. 1
   その他was evaporated
2. 2
   workup.DISSOLUTIONthe residue dissolved in dimethoxy ethane (25 ml)
3. 3
   workup.ADDITIONDBU (1,8-diazabicyclo[5.4.0]undec-7-en) was added (1.78 g)
4. 4
   温度the reaction mixture heated
5. 5
   温度under reflux for 1 hour

実験手順

A solution of 2-(4-fluoro-phenyl)-1-phenyl-ethylamine (1.50 g) in THF was treated dropwise with 2-chloroethyl isocyanate (0.89 g) at 0° C. After stirring overnight at room temperature the solvent was evaporated and the residue dissolved in dimethoxy ethane (25 ml). DBU (1,8-diazabicyclo[5.4.0]undec-7-en) was added (1.78 g) and the reaction mixture heated under reflux for 1 hour. Column chromatography on silica yielded 1.3 g of the title compound.

出典