反応 #1524

反応方程式

4-hydroxymethyl-4'-decyloxybiphenyl

HBr

→

4'-bromomethyl-4-decyloxybiphenyl

反応条件

後処理

1. 1
   その他After completion of the reaction
2. 2
   抽出the resultant mixture was extracted with ether
3. 3
   洗浄washed with water, which
4. 4
   洗浄was further washed with an aqueous solution
5. 5
   workup.ADDITIONcontaining saturated NaHCO3
6. 6
   洗浄washed again with water
7. 7
   濃縮The reaction product was concentrated
8. 8
   その他separated by colomun chromatography

実験手順

To 0.81 g (2.51 mmol) of 4-hydroxymethyl-4'-decyloxybiphenyl was added 15 ml of an aqueous solution containing 47% HBr, and then healed at 115° C. for 3 hours. After completion of the reaction, the resultant mixture was extracted with ether and washed with water, which was further washed with an aqueous solution containing saturated NaHCO3 and washed again with water. The reaction product was concentrated and, then, separated by colomun chromatography, to thereby obtain 0.92 g of 4'-bromomethyl-4-decyloxybiphenyl.

出典