反応 #1523

反応方程式

LiAlH4

4'-decyloxy-4-biphenylcarboxylic acid

→

4-hydroxymethyl-4'-decyloxybiphenyl

溶媒

diethyl ether

diethyl ether

反応条件

後処理

1. 1
   workup.ADDITIONTo the mixture was dropwise added a solution
2. 2
   その他prepared
3. 3
   workup.STIRRINGwhich was then continuously stirred for 5 days
4. 4
   その他the consumption of the raw material by TLC
5. 5
   workup.ADDITIONto the resultant mixture was added 40 ml of water
6. 6
   workup.ADDITIONfurther added concentrated hydrochloric acid until the aqueous phase
7. 7
   workup.STIRRINGwas approximately homogenized
8. 8
   抽出The resultant solution was extracted with diethyl ether
9. 9
   その他dried

実験手順

0.81 g (21.34 mmol) of LiAlH4 was introduced into 40 ml of diethyl ether and stirred. To the mixture was dropwise added a solution, prepared by introducing 1.71 g (5.06 mmol) of 4'-decyloxy-4-biphenylcarboxylic acid obtained in the first stage of Example 11 into 30 ml of diethyl ether, at room temperature over a period of 2 to 3 minutes, which was then continuously stirred for 5 days. After confirming the consumption of the raw material by TLC, to the resultant mixture was added 40 ml of water, and further added concentrated hydrochloric acid until the aqueous phase was approximately homogenized. The resultant solution was extracted with diethyl ether and dried, to obtain 4-hydroxymethyl-4'-decyloxybiphenyl.

出典