反応 #1521

反応方程式

4-((R)-1-trifluoromethylheptyloxycarbonyl)benzoic acid benzyl ester

hydrogen

→

4-((R)-1-trifluoromethylheptyloxycarbonyl)benzoic acid

収率 98.9%

溶媒

tetrahydrofuran

反応条件

後処理

1. 1
   その他5% palladium/carbon was removed
2. 2
   濃縮the filtrate was concentrated
3. 3
   その他The concentrate obtained
4. 4
   その他was purified by column chromatography

実験手順

Then, 0.07 g of 5% palladium/carbon and 10 ml of a tetrahydrofuran solution containing 0.63 g of 4-((R)-1-trifluoromethylheptyloxycarbonyl)benzoic acid benzyl ester were stirred overnight at room temperature in a stream of hydrogen to decompose a benzyl protective group by hydrogenation. 5% palladium/carbon was removed using Celite as a filter aid, and the filtrate was concentrated. The concentrate obtained was purified by column chromatography to obtain 0.49 g of 4-((R)-1-trifluoromethylheptyloxycarbonyl)benzoic acid as a colorless liquid (gradually crystallized) (isolated yield: 98%).

出典