反応 #1519121

反応方程式

TMSCl

1H-1,2,3-triazole

→

TMS-triazole

溶媒

benzene

benzene

反応条件

後処理

1. 1
   その他Reaction mixture
2. 2
   その他The resultant precipitate is removed by filtration
3. 3
   洗浄washed thoroughly with dry benzene
4. 4
   濃縮The filtrate is gently concentrated
5. 5
   その他to avoid evaporating the highly volatile product

実験手順

To a solution of 1H-1,2,3-triazole (4.98 g, 72.10 mmol, 1 equiv.) in dry benzene (145 mL) at rt under nitrogen, is added TEA (11.05 mL, 79.31 mmol, 1.1 equiv.) followed by the dropwise addition of TMSCl (9.15 mL, 72.10 mmol, 1 equiv.). A white precipitate develops. Reaction mixture is stirred at rt under nitrogen for 1 hour. The resultant precipitate is removed by filtration and washed thoroughly with dry benzene. The filtrate is gently concentrated to avoid evaporating the highly volatile product to give a quantitative yield of TMS-triazole with a trace of benzene.

出典