反応 #1519120

反応方程式

Z-L-Pro-OH

thionyl chloride

→

Z-L-Pro-Cl

溶媒

DCM

反応条件

後処理

1. 1
   温度is heated
2. 2
   温度to reflux under nitrogen for 20 minutes
3. 3
   濃縮concentrated in vacuo
4. 4
   濃縮concentrated

実験手順

A mixture of Z-L-Pro-OH E-1 (10.0 g, 40.1 mmol, 1 equiv.) and thionyl chloride (30 mL, 401.2 mmol, 10 equiv.) in DCM (200 mL) is heated to reflux under nitrogen for 20 minutes and concentrated in vacuo. The residual oil is coevaporated with toluene 3×, and concentrated to give Z-L-Pro-Cl as an opaque oil.

出典