反応 #1519118

反応方程式

(2S,3R)-3-(n-butyl)-2-hydroxysuccinic acid

p-TSA

→

2-(2,2-dimethyl-4-oxo-1,3-dioxolan-5-yl)hexanoic acid

溶媒

DCM

2,2-dimethoxypropane

反応条件

後処理

1. 1
   洗浄washed with brine
2. 2
   乾燥dried (Na2SO4)
3. 3
   その他purified by silica gel chromatography

実験手順

To a solution of (2S,3R)-3-(n-butyl)-2-hydroxysuccinic acid B-4 (300 mg, 1.58 mmol) in 2,2-dimethoxypropane (10 mL) is added p-TSA (20 mg) and the reaction is stirred at rt for 16 hours. The solution is diluted with DCM and washed with brine, dried (Na2SO4) and then purified by silica gel chromatography to afford 1.2 mmol 2-(2,2-dimethyl-4-oxo-1,3-dioxolan-5-yl)hexanoic acid B-5.

出典