反応 #1519117

反応方程式

(2S,3R)-3-(n-butyl)-2-hydroxysuccinic dimethyl ester

NaOH

HCl

→

(2S,3R)-3-(n-butyl)-2-hydroxysuccinic acid

溶媒

MeOH

water

反応条件

後処理

1. 1
   その他the MeOH is removed
2. 2
   その他the crude reaction
3. 3
   抽出extracted with EtOAc (3×50 mL)
4. 4
   乾燥The combined organic layers are dried (Na2SO4)
5. 5
   濃縮concentrated

実験手順

To (2S,3R)-3-(n-butyl)-2-hydroxysuccinic dimethyl ester B-3 in MeOH (28 mL) is added a solution of NaOH (2.2 g, 55 mmol) in water (28 mL). After 24 hours, the MeOH is removed, the crude reaction is acidified with HCl (6 N, 12 mL) to pH=1, and then extracted with EtOAc (3×50 mL). The combined organic layers are dried (Na2SO4) and concentrated to give (2S,3R)-3-(n-butyl)-2-hydroxysuccinic acid B-4.

出典