反応 #1519110

反応方程式

sodium hydride

2-cyanopyridine

guanidine hydrochloride

→

4,6-di-pyrid-2-yl-[1,3,5]triazin-2-ylamine

溶媒

dimethyl sulfoxide

反応条件

後処理

1. 1
   workup.WAITfor 23 hours at 75° C
2. 2
   温度The mixture is cooled
3. 3
   ろ過filtered

実験手順

1.0 g (approximately 60% dispersion in paraffin oil, about 25 mmol) of sodium hydride is added in portions to a mixture of 5.21 g (50 mmol) of 2-cyanopyridine and 2.39 g (25 mmol) of guanidine hydrochloride in 100 ml of dimethyl sulfoxide. Stirring is carried out for 2 hours at room temperature, and then for 23 hours at 75° C. The mixture is cooled and poured into 100 ml of ice-water and filtered, yielding 4,6-di-pyrid-2-yl-[1,3,5]triazin-2-ylamine in the form of a white solid after drying in vacuo.

出典