反応 #1519108

反応方程式

6-(4-chloropyrid-2-yl)-2-pyrid-2-yl-pyrimidin-4-ol

2-amidinopyridine hydrochloride

2-amidino-4-chloropyridine hydrochloride

→

2,6-Bis(4-chloropyrid-2-yl)-pyrimidin-4-ol

反応条件

後処理

1. 1
   その他After recrystallisation from DMSO, 2,6-bis(4-chloropyrid-2-yl)-pyrimidin-4-ol (ligand PM5)is
2. 2
   その他obtained in the form of a colourless solid

実験手順

The procedure is as described in the case of 6-(4-chloropyrid-2-yl)-2-pyrid-2-yl-pyrimidin-4-ol (ligand PM1) in Example 3 except that, instead of 2-amidinopyridine hydrochloride, the 2-amidino-4-chloropyridine hydrochloride from Example 8 is used. After recrystallisation from DMSO, 2,6-bis(4-chloropyrid-2-yl)-pyrimidin-4-ol (ligand PM5)is obtained in the form of a colourless solid. 1H-NMR (360 MHz, DMSO-d6): 12.53 (br s, 1H): 8.74 (d, J=5.0 Hz, 1H): 8.74 (s, 1H): 8.71 (d, J=5.0 Hz, 1H): 8.64 (d, J=2.3 Hz, 1H): 7.83 (dd, J=5.0, 2.3 Hz, 1H); 7.71 (dd, J=5.0, 2.3 Hz, 1H): 7.30 (s, 1H).

出典