反応 #1519107

反応方程式

ammonium chloride

4-chloro-2-cyanopyridine

sodium methoxide

→

2-amidino-4-chloropyridine hydrochloride

溶媒

methanol

反応条件

後処理

1. 1
   温度refluxing
2. 2
   その他The volatile components are then removed in vacuo

実験手順

6.93 g (50 mmol) of 4-chloro-2-cyanopyridine in 40 ml of methanol are treated for one hour with 0.27 g (5 mmol) sodium methoxide. After the addition of 3.00 g (56 mmol) of ammonium chloride, refluxing is carried out for two hours. The volatile components are then removed in vacuo. The 2-amidino-4-chloropyridine hydrochloride so obtained is reacted without further purification.

出典