反応 #1519099

反応方程式

ether

methoxyethoxymethyl chloride

4-iodophenol

sodium hydride

→

4-Methoxyethoxymethoxy-iodobenzene

溶媒

tetrahydrofuran

反応条件

後処理

1. 1
   温度warmed to room temperature
2. 2
   workup.STIRRINGstirred under nitrogen for 24 hours
3. 3
   その他The solvent was removed under reduced pressure
4. 4
   洗浄washed with 200 mL of 5% sodium hydroxide (4×200 mL), water (4×200 mL), saturated sodium chloride (1×200 mL)
5. 5
   乾燥dried over sodium sulfate
6. 6
   その他Evaporation of the solvent under reduced pressure
7. 7
   その他gave an oily product in 14.1 g

実験手順

A solution of 4-iodophenol (10 g, 45.45 mmoles) in 200 mL of anhydrous tetrahydrofuran was treated at 0° C. with sodium hydride (2.36 g, 60% dispersion, 59.09 mmoles) for 5 minutes. To the resulting mixture was slowly added over a 5 minute period methoxyethoxymethyl chloride (8.3 mL, 72.73 mmoles). The mixture was stirred at 0° C. for 30 minutes, warmed to room temperature, and stirred under nitrogen for 24 hours. The solvent was removed under reduced pressure. The residue was taken into 500 mL of ether, washed with 200 mL of 5% sodium hydroxide (4×200 mL), water (4×200 mL), saturated sodium chloride (1×200 mL), and dried over sodium sulfate. Evaporation of the solvent under reduced pressure gave an oily product in 14.1 g. TLC (silica gel, ether): Rf 0.5.

出典