反応 #1519079

反応方程式

2-ethylhexyl (2,6-dimethyl-pyran-4-ylidene)cyanoacetate

→

2-ethylhexyl (1-N-butyl-2,6-dimethyl-1H-pyridin-4-ylidene)cyanoacetate

収率 128.3%

溶媒

butylamine

反応条件

後処理

1. 1
   その他Removal of the excess of butylamine at reduced pressure
2. 2
   workup.WAITleft a orange oil which
3. 3
   その他was purified by FC (n-hexane/EtOAc 1:1)

実験手順

A solution of 0.30 g (1 mmol) of 2-ethylhexyl (2,6-dimethyl-pyran-4-ylidene)cyanoacetate (prepared as described in example 1) in 4 ml butylamine was refluxed at 80° C. for 1 h under nitrogen. Removal of the excess of butylamine at reduced pressure left a orange oil which was purified by FC (n-hexane/EtOAc 1:1) yielding 0.23 g (64%) of 2-ethylhexyl (1-N-butyl-2,6-dimethyl-1H-pyridin-4-ylidene)cyanoacetate as a slightly yellow solid.

出典