反応 #1519078

反応方程式

(2,6-dimethyl-4H-pyran-4-ylidene)malononitril

2-ethyl-1-hexylamine

→

1-N-(2-ethylhexyl)-4-dicyanomethylene-2,6-dimethyl-1,4-dihydropyridine

反応条件

後処理

1. 1
   その他Removal of the excess of ethyl-1-hexylamine at reduced pressure
2. 2
   workup.WAITleft a solid which
3. 3
   その他was recrystallized from 15 ml EtOAc/MeOH 2/1 yielding 0.45 g (55%) of 1-N-(2-ethylhexyl)-4-dicyanomethylene-2,6-dimethyl-1,4-dihydropyridine

実験手順

A solution of 0.5 g (2.9 mmol) of (2,6-dimethyl-4H-pyran-4-ylidene)malononitril in 7.6 ml (6 g, 46.4 mmol) 2-ethyl-1-hexylamine was refluxed for 1 h under nitrogen. Removal of the excess of ethyl-1-hexylamine at reduced pressure left a solid which was recrystallized from 15 ml EtOAc/MeOH 2/1 yielding 0.45 g (55%) of 1-N-(2-ethylhexyl)-4-dicyanomethylene-2,6-dimethyl-1,4-dihydropyridine.

出典