反応 #1515

反応方程式

1,2,3,4-tetrahydro-6-hydroxynaphthalene-2-carboxylic acid (R)-1-methylheptyl ester

N,N'-dicyclohexylcarbodiimide

4'-octylbiphenyl-4-carboxylic acid

(R)-1-trifluoromethylheptanol

→

6-(4'-octylbiphenylcarbonyloxy)-1,2,3,4-tetrahydro-2-naphthalenecarboxylic acid (R)-1-methylheptyl ester

溶媒

methylene chloride

methylene chloride

反応条件

後処理

1. 1
   その他obtained as in the fourth stage of Example 23 where R-1-methyl heputanol

実験手順

To a mixture of 0.31 g (1 mmol) of 1,2,3,4-tetrahydro-6-hydroxynaphthalene-2-carboxylic acid (R)-1-methylheptyl ester obtained as in the fourth stage of Example 23 where R-1-methyl heputanol was used in stead of (R)-1-trifluoromethylheptanol, 0.31 g (1 mmol) of 4'-octylbiphenyl-4-carboxylic acid (FK-1124-8 from Teikoku Kagaku Sangyo K.K.), 0.02 g (0.16 mmol) of 4-N,N-dimethylaminopyridine and 15 ml of methylene chloride was added dropwise 3 ml of a methylene chloride solution containing 0.27 g (1.3 mmol) of N,N'-dicyclohexylcarbodiimide with stirring at room temperature over a period of 3 hours.

出典