反応 #1511328

反応方程式

(S)-3-(tert-butoxycarbonyl)-2,2-dimethyloxazolidine-4-carboxylic acid

3′,4′-diaminobiphenyl-4-carbonitrile

→

title compound

4-{2-[(1R)-1-Amino-2-hydroxyethyl]-1H-benzimidazol-5-yl}benzonitrile

反応条件

後処理

1. 1
   その他The residue was purified through an SCX cartridge
2. 2
   洗浄eluting with 0-60% MeCN in water

実験手順

The title compound was prepared according to Method 1 using (S)-3-(tert-butoxycarbonyl)-2,2-dimethyloxazolidine-4-carboxylic acid and 3′,4′-diaminobiphenyl-4-carbonitrile (Preparation 82). The residue was purified through an SCX cartridge followed by reverse phase column chromatography eluting with 0-60% MeCN in water.

出典