反応 #1509597
ord-a15aac5b07ea49c6bd015a4ccf3331e2
反応方程式
dimethylamine
2-Chloro-6-methyl-isonicotinic acid
DIPEA
TBTU
→
title compound
2-Chloro-6,N,N-trimethyl-isonicotinamide
反応条件
詳細条件
See reaction.notes.procedure_details.
後処理
- 1抽出extracted with EtOAc
- 2その他The organic layer was separated
- 3その他dried
- 4濃縮concentrated in vacuum
実験手順
To a solution of 2-Chloro-6-methyl-isonicotinic acid (1 g) in DMF (200 ml) at 25° C. was added DIPEA (2.9 mL) and TBTU (1.8 ml). After 5 min, dimethylamine (0.75 g) was added dropwise. This was stirred overnight. The reaction was added to water and extracted with EtOAc. The organic layer was separated, dried and concentrated in vacuum. Flash:chromatography (9:1 to 2:8 gradient cyclohexane:EtOAc) afforded the title compound (320 mg). Rf=0.56 (1:1 cyclohexane:EtOAc)