反応 #1509592

反応方程式

3-(1-Methyl-1H-tetrazol-5-yl)-5-nitro-benzoic acid ethyl ester

→

title compound

収率 72.5%

3-Amino-5-(1-methyl-1H-tetrazol-5-yl)-benzoic acid ethyl ester

収率 72.5%

溶媒

EtOAc ethanol

反応条件

後処理

1. 1
   その他was hydrogenated at 20° C.
2. 2
   その他After reaction completion
3. 3
   ろ過the mixture was filtered
4. 4
   濃縮the filtrate concentrated in vacuum

実験手順

A solution of 3-(1-Methyl-1H-tetrazol-5-yl)-5-nitro-benzoic acid ethyl ester (6.5 g) in EtOAc:ethanol (1:1, 320 ml) was hydrogenated at 20° C. and 50 psi with 10% Pd/C (750 mg). After reaction completion, the mixture was filtered and the filtrate concentrated in vacuum to give the title compound (4.2 g). Rt=1.21 min (method D).

出典