反応 #1509583

反応方程式

3-Nitro-benzyl-amine

cyclohexyl isocyanate

→

1-Cyclohexyl-3-(3-nitro-benzyl)-urea

溶媒

THF

反応条件

後処理

1. 1
   ろ過was filtered off
2. 2
   洗浄washed with diethyl ether
3. 3
   workup.ADDITIONtreated with 5% aqueous NH4OH
4. 4
   ろ過After filtering
5. 5
   乾燥drying the title compound
6. 6
   その他was isolated (4.5 g, FP 168-169° C.)

実験手順

3-Nitro-benzyl-amine (5 g) was suspended in THF (130 ml) and cyclohexyl isocyanate (7 ml) was added dropwise at 25° C. After stirring for 2 h the resulting precipitate was filtered off, washed with diethyl ether and treated with 5% aqueous NH4OH. After filtering and drying the title compound was isolated (4.5 g, FP 168-169° C.)

出典