反応 #1509580

反応方程式

thiourea

Ethyl 2-bromo-4-methyl-3-oxopentanoate

→

product

収率 40.6%

Ethyl 2-amino-4-isopropylthiazole-5-carboxylate

収率 40.6%

溶媒

ethanol

反応条件

後処理

1. 1
   温度to reflux
2. 2
   温度the reaction mixture refluxed further for 1 h
3. 3
   濃縮was concentrated in vacuum

実験手順

A solution of thiourea (1.1 g) in ethanol (10 mL) was brought to reflux. Ethyl 2-bromo-4-methyl-3-oxopentanoate (3.0 g) was then added and the reaction mixture refluxed further for 1 h. The reaction was complete (by TLC) and was concentrated in vacuum. Flash chromatography (100% DCM→90:10 DCM:MeOH) afforded the product (1.1 g).

出典