反応 #1509575

反応方程式

5-(3-Bromo-5-nitro-phenyl)-1-methyl-1H-tetrazole

→

title compound

収率 15.4%

3-Bromo-5-(1-methyl-1H-tetrazol-5-yl)-phenylamine

収率 15.4%

溶媒

EtOAc

反応条件

後処理

1. 1
   その他was hydrogenated on a H-cube® apparatus at 20° C.
2. 2
   その他After reaction completion
3. 3
   濃縮the mixture was concentrated in vacuum
4. 4
   その他triturated with MeOH
5. 5
   ろ過The solid was filtered
6. 6
   その他further triturated
7. 7
   その他air-dried

実験手順

A solution of 5-(3-Bromo-5-nitro-phenyl)-1-methyl-1H-tetrazole (2.1 g) in EtOAc (100 ml) was hydrogenated on a H-cube® apparatus at 20° C., room pressure with a flow rate of 1 ml/min using a Raney-Ni cartridge. After reaction completion, the mixture was concentrated in vacuum and triturated with MeOH. The solid was filtered and further triturated and air-dried to give the title compound (290 mg). Rt 1.25 min (method D).

出典