反応 #1502

反応方程式

Chloromethyl chloroformate

cholesterol

Pyridine

→

3-(Chloromethoxycarbonyl) Cholesterol

溶媒

CH2Cl2

CH2Cl2

反応条件

後処理

1. 1
   温度The solution was cooled
2. 2
   温度Heat
3. 3
   その他was produced
4. 4
   その他the reaction gave a clear solution from
5. 5
   洗浄washed with 0.5M HCl (50 ml) and water (3×25 ml)
6. 6
   その他After treatment with MgSO4, the solution was evaporated to dryness

実験手順

Chloromethyl chloroformate (1.96 g, 15.2 mmol) and cholesterol (5.0 g, 12.9 mmol) was dissolved in CH2Cl2 (10 ml). The solution was cooled. Pyridine (1.21 g, 15.3 mmol) was dripped into the stirred solution over 5 minutes. Heat was produced and the reaction gave a clear solution from a somewhat unclear starting solution. After 24 hours at room temperature, the mixture was diluted with CH2Cl2 (50 ml), washed with 0.5M HCl (50 ml) and water (3×25 ml). After treatment with MgSO4, the solution was evaporated to dryness.

出典