反応 #1492201

反応方程式

4-chloro-5-iodo-6-methyl-pyrimidin-2-ylamine

3-ethynyl-pyridine

triethylamine

→

title compound

4-Chloro-6-methyl-5-pyridin-3-ylethynyl-pyrimidin-2-ylamine

溶媒

DMF

反応条件

後処理

1. 1
   濃縮For the work-up the reaction mixture is concentrated in vacuo before water
2. 2
   workup.ADDITIONis added
3. 3
   その他The precipitate is collected
4. 4
   その他dried at 40° C.
5. 5
   その他crystallized from MeOH/H2O

実験手順

The title compound is synthesized according to general procedure GP2 starting from 4.0 g (15 mmol) 4-chloro-5-iodo-6-methyl-pyrimidin-2-ylamine (GP3) and 2.0 g (19 mmol) 3-ethynyl-pyridine using 282 mg (1.5 mmol) CuI, 1.0 g (1.5 mmol) PdCl2(PPh3)2 and 21 mL (148 mmol) triethylamine in 200 mL dry DMF. For the work-up the reaction mixture is concentrated in vacuo before water is added. The precipitate is collected, dried at 40° C. and crystallized from MeOH/H2O. Yield: 3.0 g (83%).

出典