反応 #1478579

反応方程式

para-fluoronitrobenzene

N-methyl-pyrrolidinone

1-(3-aminopropyl)-2-pipecoline

triethylamine

→

N-[3-(2-methyl-piperidin-1-yl)propyl]-4-nitro-1-aminobenzene

収率 75.1%

N-[3-(2-Methylpiperidin-1-yl)propyl]-4-nitro-1-aminobenzene

収率 75.1%

溶媒

water

反応条件

後処理

1. 1
   温度after cooling to room temperature
2. 2
   その他The yellow precipitate formed
3. 3
   ろ過was filtered off
4. 4
   乾燥dried over P2O5

実験手順

2 g of para-fluoronitrobenzene were added to a solution of 20 ml of N-methyl-pyrrolidinone, 1.65 g of 1-(3-aminopropyl)-2-pipecoline and 1.72 g of triethylamine. The reaction medium was heated at 60° C. for 8 hours and, after cooling to room temperature, was then poured into a water and ice mixture. The yellow precipitate formed was filtered off, reslurried in water and then dried over P2O5. 2.2 g of N-[3-(2-methyl-piperidin-1-yl)propyl]-4-nitro-1-aminobenzene (17) were obtained.

出典