反応 #1478575

反応方程式

4-fluoronitrobenzene

N-methyl-pyrrolidine

N-(3-aminopropyl)-N′-methylpiperazine

K2CO3

→

N-[3-(4-methyl-piperazin-1-yl)propyl]-4-nitro-1-aminobenzene

収率 81.6%

N-[3-(4-methylpiperazin-1-yl)propyl]-4-nitro-1-aminobenzene

収率 81.6%

溶媒

water

反応条件

後処理

1. 1
   温度after cooling to room temperature
2. 2
   その他The yellow precipitate formed
3. 3
   ろ過was filtered off
4. 4
   乾燥dried over P2O5

実験手順

2 g of 4-fluoronitrobenzene were added to a solution of 20 ml of N-methyl-pyrrolidine, 2.67 g of N-(3-aminopropyl)-N′-methylpiperazine and 2.35 g of K2CO3. The reaction medium was heated at 60° C. for 10 hours and, after cooling to room temperature, was then poured into a water and ice mixture. The yellow precipitate formed was filtered off, reslurried in water and then dried over P2O5. 3.22 g of N-[3-(4-methyl-piperazin-1-yl)propyl]-4-nitro-1-aminobenzene (9) were obtained.

出典